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Ent-kauren-19-oic acid derivatives from the stem bark of Croton pseudopulchellus Pax

Langat, MK, Mulholland, DA, Langat, MK, Crouch, NR, Mulholland, DA, Crouch, NR, Pohjala, L, Tammela, P, Pohjala, L and Smith, PJ (2012) Ent-kauren-19-oic acid derivatives from the stem bark of Croton pseudopulchellus Pax Phytochemistry Letters, 5 (3). pp. 414-418.

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Two new ent-kauren-19-oic acid derivatives, ent-14S*-hydroxykaur-16-en-19-oic acid and ent-14S*,17-dihydroxykaur-15-en-19-oic acid together with eleven known compounds ent-kaur-16-en-19-oic acid, ent-kaur-16-en-19-al, ent-12β-hydroxykaur-16-en-19-oic acid, ent-12β-acetoxykaur-16-en-19-oic acid, 8R,13R-epoxylabd-14-ene, eudesm-4(15)-ene-1β,6α-diol, (-)-7-epivaleran-4-one, germacra-4(15), 5E,10(14)-trien-9β-ol, acetyl aleuritolic acid, β-amyrin, and stigmasterol were isolated from the stem bark of Croton pseudopulchellus (Euphorbiaceae). Structures were determined using spectroscopic techniques. Ent-14S*-hydroxykaur-16-en-19-oic acid, ent-kaur-16-en-19-oic acid, ent-12β-hydroxykaur-16-en-19-oic acid, ent-12β-acetoxykaur-16-en-19-oic acid and 8R,13R-epoxylabd-14-ene were tested for their effects on Semliki Forest virus replication and for cytotoxicity against human liver tumour cells (Huh-7 strain) but were found to be inactive. Ent-kaur-16-en-19-oic acid, the major constituent, showed weak activity against the Plasmodium falciparum (CQS) D10 strain. © 2012 Phytochemical Society of Europe.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
Langat, MK
Mulholland, DA
Langat, MK
Crouch, NR
Mulholland, DA
Crouch, NR
Pohjala, L
Tammela, P
Pohjala, L
Smith, PJ
Date : 2012
DOI : 10.1016/j.phytol.2012.03.002
Additional Information : NOTICE: this is the author’s version of a work that was accepted for publication in Phytochemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Phytochemistry Letters, 5(3), September 2012, DOI 10.1016/j.phytol.2012.03.002.
Depositing User : Symplectic Elements
Date Deposited : 21 Dec 2012 11:59
Last Modified : 31 Oct 2017 14:56

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