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Metal-responsive gene regulation and metal transport in Helicobacter species

Belzer, C, Stoof, J and van Vliet, AH (2007) Metal-responsive gene regulation and metal transport in Helicobacter species Biometals, 20. pp. 417-429.

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Helicobacter species are among the most successful colonizers of the mammalian gastrointestinal and hepatobiliary tract. Colonization is usually lifelong, indicating that Helicobacter species have evolved intricate mechanisms of dealing with stresses encountered during colonization of host tissues, like restriction of essential metal ions. The recent availability of genome sequences of the human gastric pathogen Helicobacter pylori, the murine enterohepatic pathogen Helicobacter hepaticus and the unannotated genome sequence of the ferret gastric pathogen Helicobacter mustelae has allowed for comparitive genome analyses. In this review we present such analyses for metal transporters, metal-storage and metal-responsive regulators in these three Helicobacter species, and discuss possible contributions of the differences in metal metabolism in adaptation to the gastric or enterohepatic niches occupied by Helicobacter species.

Item Type: Article
Subjects : Veterinary Medicine
Divisions : Surrey research (other units)
Authors :
Belzer, C
Stoof, J
van Vliet,
Date : 9 February 2007
DOI : 10.1007/s10534-006-9028-9
Copyright Disclaimer : Springer Science+Business Media B.V. 2007
Uncontrolled Keywords : Helicobacter Microbial pathogenesis Gastrointestinal and hepatobiliary tract Metal-responsive regulation Metal transport
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:47
Last Modified : 24 Jan 2020 20:02

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