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Synthesis of amino-substituted indoles using the Bartoli reaction

Wylie, L, Innocenti, P, Whelligan, DK and Hoelder, S (2012) Synthesis of amino-substituted indoles using the Bartoli reaction Org Biomol Chem, 10 (22). pp. 4441-4447.

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We report herein the concise preparation of a range of functionalised aminoindoles via a new application of the Bartoli reaction. Scope and limitations of the methodology have been extensively studied to reveal the importance of protecting groups and substitution patterns. The use of amino substituted nitroanilines for the Bartoli reaction is to our knowledge unprecedented. Our work thus represents a novel entry into substituted aminoindoles which are relevant building blocks for both the fine chemical and pharmaceutical industry.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Wylie, L
Innocenti, P
Hoelder, S
Date : 14 June 2012
DOI : 10.1039/c2ob25256b
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 12:25
Last Modified : 24 Jan 2020 22:13

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