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What is the evidence for a role for diet and nutrition in osteoarthritis?

Thomas, Sally, Browne, Heather, Mobasheri, Ali and Rayman, Margaret (2018) What is the evidence for a role for diet and nutrition in osteoarthritis? Rheumatology, 57 (supp.4). iv61-iv74.

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As current treatment options in OA are very limited, OA patients would benefit greatly from some ability to self-manage their condition. Since diet may potentially affect OA, we reviewed the literature on the relationship between nutrition and OA risk or progression, aiming to provide guidance for clinicians. For overweight/obese patients, weight reduction, ideally incorporating exercise, is paramount. The association between metabolic syndrome, type-2 diabetes and OA risk or progression may partly explain the apparent benefit of dietary-lipid modification resulting from increased consumption of long-chain omega-3 fatty-acids from oily fish/fish oil supplements. A strong association between OA and raised serum cholesterol together with clinical effects in statin users suggests a potential benefit of reduction of cholesterol by dietary means. Patients should ensure that they meet the recommended intakes for micronutrients such as vitamin K, which has a role in bone/cartilage mineralization. Evidence for a role of vitamin D supplementation in OA is unconvincing.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
Thomas, Sally
Browne, Heather
Date : 17 April 2018
DOI : 10.1093/rheumatology/key011
Copyright Disclaimer : © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords : Nutrition; Osteoarthritis (OA); Obesity; Diabetes; Metabolic syndrome; Polyunsaturated fatty acids (PUFAs); Cholesterol; Anti-oxidants; Vitamin D; Vitamin K
Depositing User : Clive Harris
Date Deposited : 21 Dec 2017 09:21
Last Modified : 26 Oct 2018 09:58

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