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Immune system changes and immunosenescence

Pawelec, Graham, Müller, Ludmila, Fülöp, Tamas and Dunn-Walters, Deborah (2017) Immune system changes and immunosenescence In: Oxford Textbook of Geriatric Medicine. Oxford University Press, Oxford, UK. ISBN 9780198701590

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The immune system defends against infection, but older people paradoxically suffer not only from failing immunity resulting in increased susceptibility to infections and decreased responsiveness to vaccination, but at the same time increased inflammation and immunopathology accompanying immune responses. Interventions to reduce such deleterious effects while enhancing protective immunity are challenging but need to be confronted if we are to deal successfully with the increasing numbers of elderly and frail people in modern societies. To do this, we need to understand the mechanisms responsible for age-associated increased susceptibility to infections and immune-influenced chronic degenerative diseases of ageing. Defining relevant age-associated alterations and identifying reliable biomarkers for monitoring clinically-relevant immune status in the elderly population is crucial to overcoming these problems. Here, we briefly outline age-associated changes to immunity collectively termed ‘immunosenescence’

Item Type: Book Section
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Pawelec, Graham
Müller, Ludmila
Fülöp, Tamas
Editors :
Michel, Jean-Pierre
Beattie, B. Lynn
Martin, Finbarr C.
Walston, Jeremy D.
Date : December 2017
DOI : 10.1093/med/9780198701590.003.0045
Copyright Disclaimer : Oxford University Press Copyright © 2017. All rights reserved.
Depositing User : Karen Garland
Date Deposited : 11 Jan 2018 14:57
Last Modified : 16 Jan 2019 19:06

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