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Selenium, selenoprotein P, and Alzheimer's disease: is there a link?

Solovyev, Nikolay, Drobyshev, Evgenii, Bjørklund, Geir, Dubrovskii, Yaroslav, Lysiuk, Roman and Rayman, Margaret (2018) Selenium, selenoprotein P, and Alzheimer's disease: is there a link? Free Radical Biology and Medicine, 127. pp. 124-133.

Selenium, selenoprotein P, and Alzheimer's disease.pdf - Accepted version Manuscript

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The essential trace element, selenium (Se), is crucial to the brain but it may be potentially neurotoxic, depending on dosage and speciation; Se has been discussed for decades in relation to Alzheimer's disease (AD). Selenoprotein P (SELENOP) is a secreted heparin-binding glycoprotein which serves as the main Se transport protein in mammals. In vivo studies showed that this protein might have additional functions such as a contribution to redox regulation. The current review focuses on recent research on the possible role of SELENOP in AD pathology, based on model and human studies. The review also briefly summarizes results of epidemiological studies on Se supplementation in relation to brain diseases, including PREADViSE, EVA, and AIBL. Although mainly positive effects of Se are assessed in this review, possible detrimental effects of Se supplementation or exposure, including potential neurotoxicity, are also mentioned. In relation to AD, various roles of SELENOP are discussed, i.e. as the means of Se delivery to neurons, as an antioxidant, in cytoskeleton assembly, in interaction with redox-active metals (copper, iron, and mercury) and with misfolded proteins (amyloid-beta and hyperphosphorylated tau-protein).

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Solovyev, Nikolay
Drobyshev, Evgenii
Bjørklund, Geir
Dubrovskii, Yaroslav
Lysiuk, Roman
Date : 2 March 2018
DOI : 10.1016/j.freeradbiomed.2018.02.030
Copyright Disclaimer : © 2018 Published by Elsevier B.V. This article is made available under the CC-BY-NC-ND license 4.0
Uncontrolled Keywords : Alzheimer's disease; Neurodegeneration; Selenium; Selenoprotein P; Brain; Oxidative stress; Redox regulation; Human studies; Model studies; Supplementation; Amyloid-beta; Trace elements
Depositing User : Clive Harris
Date Deposited : 25 Apr 2018 07:46
Last Modified : 03 Mar 2019 02:08

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