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In vivo dynamic optical coherence elastography using a ring actuator

Kennedy, B.F., Hillman, T.R., McLaughlin, R.A., Quirk, B.C. and Sampson, David (2009) In vivo dynamic optical coherence elastography using a ring actuator Optics Express, 17 (24). pp. 21762-21772.

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We present a novel sample arm arrangement for dynamic optical coherence elastography based on excitation by a ring actuator. The actuator enables coincident excitation and imaging to be performed on a sample, facilitating in vivo operation. Sub-micrometer vibrations in the audio frequency range were coupled to samples that were imaged using optical coherence tomography. The resulting vibration amplitude and microstrain maps are presented for bilayer silicone phantoms and multiple skin sites on a human subject. Contrast based on the differing elastic properties is shown, notably between the epidermis and dermis. The results constitute the first demonstration of a practical means of performing in vivo dynamic optical coherence elastography on a human subject.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Kennedy, B.F.
Hillman, T.R.
McLaughlin, R.A.
Quirk, B.C.
Date : 2009
DOI : 10.1364/OE.17.021762
Uncontrolled Keywords : Actuators, Optical tomography, Silicones, Audio frequencies, Bi-layer, Elastic properties, Human subjects, Micro-strain, Optical coherence elastography, Submicrometers, Vibration amplitude, Medical imaging, adult, algorithm, article, computer assisted diagnosis, elastography, equipment design, human, image quality, instrumentation, interferometry, male, methodology, optical coherence tomography, pathology, radiation scattering, skin, Adult, Algorithms, Elasticity Imaging Techniques, Equipment Design, Humans, Image Interpretation, Computer-Assisted, Interferometry, Male, Phantoms, Imaging, Scattering, Radiation, Skin, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 11 Jun 2018 07:16
Last Modified : 19 Sep 2018 11:32

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