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Audio frequency in vivo optical coherence elastography

Adie, S.G., Kennedy, B.F., Armstrong, J.J., Alexandrov, S.A. and Sampson, D.D. (2009) Audio frequency in vivo optical coherence elastography Physics in Medicine and Biology, 54 (10). pp. 3129-3139.

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We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Adie, S.G.
Kennedy, B.F.
Armstrong, J.J.
Alexandrov, S.A.
Date : 2009
DOI : 10.1088/0031-9155/54/10/011
Uncontrolled Keywords : Audio frequencies, Frequency spectra, Human skin in vivo, In-vivo, Interferometric signals, Local elastic properties, New approaches, Optical coherence elastography, Optical coherence Tomography, Periodic motion, Quantitative result, Submicron, Optical properties, Spectroscopy, Tomography, Coherent light, article, auditory discrimination, elastography, frequency analysis, human, measurement, optical coherence elastography, priority journal, skin, algorithm, auditory stimulation, computer assisted diagnosis, echography, feasibility study, image enhancement, image quality, instrumentation, methodology, optical coherence tomography, reproducibility, sensitivity and specificity, skin, Acoustic Stimulation, Algorithms, Elasticity Imaging Techniques, Feasibility Studies, Image Enhancement, Image Interpretation, Computer-Assisted, Phantoms, Imaging, Reproducibility of Results, Sensitivity and Specificity, Skin, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 06 Jun 2018 11:44
Last Modified : 19 Sep 2018 11:32

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