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Systems Pharmacology: An opinion on how to turn the impossible into grand challenges

Westerhoff, H.V., Nakayama, S., Mondeel, T.D.G.A. and Barberis, Matteo (2015) Systems Pharmacology: An opinion on how to turn the impossible into grand challenges Drug Discovery Today: Technologies, 15. pp. 23-31.

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A pharmacology that hits single disease-causing molecules with a single drug passively distributing to the target tissue, was almost ready. Such a pharmacology is not (going to be) effective however: a great many diseases are systems biology diseases; complex networks of some hundred thousand types of molecule, determine the functions that constitute human health, through nonlinear interactions. Malfunctions are caused by a variety of molecular failures at the same time; rarely the same variety in different individuals; in complex constellations of OR and AND logics. Few molecules cause disease single-handedly and few drugs will cure the disease all by themselves when dosed for a limited amount of time. We here discuss the implications that this discovery of the network nature of disease should have for pharmacology. We suggest ways in which pharmacokinetics, pharmacodynamics, but also systems biology and genomics may have to change so as better to deal with systems-biology diseases.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Westerhoff, H.V.
Nakayama, S.
Mondeel, T.D.G.A.
Date : August 2015
Funders : Biotechnology and Biological Sciences Research Council (BBSRC), European Union Seventh Framework Programme, European Union's Horizon 2020
DOI : 10.1016/j.ddtec.2015.06.006
Depositing User : Clive Harris
Date Deposited : 12 Apr 2019 12:08
Last Modified : 12 Apr 2019 12:08

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