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Obstructive sleep apnoea and Alzheimer’s disease: In search of shared pathomechanisms

Polsek, D., Gildeh, N., Cash, D., Winsky-Sommerer, R., Williams, S.C.R., Turkheimer, F., Leschziner, G.D., Morrell, M.J. and Rosenzweig, I. (2018) Obstructive sleep apnoea and Alzheimer’s disease: In search of shared pathomechanisms Neuroscience & Biobehavioral Reviews, 86. pp. 142-149.

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Alzheimer’s disease (AD) is a significant public health concern. The incidence continues to rise, and it is set to be over one million in the UK by 2025. The processes involved in the pathogenesis of AD have been shown to overlap with those found in cognitive decline in patients with Obstructive Sleep Apnoea (OSA). Currently, the standard treatment for OSA is Continuous Positive Airway Pressure. Adherence to treatment can, however, be an issue, especially in patients with dementia. Also, not all patients respond adequately, necessitating the use of additional treatments. Based on the body of data, we here suggest that excessive and prolonged neuronal activity might contribute to genesis and acceleration of both AD and OSA in the absence of appropriately structured sleep. Further, we argue that external factors, including systemic inflammation and obesity, are likely to interfere with immunological processes of the brain, and further promote disease progression. If this hypothesis is proven in future studies, it could have far-reaching clinical translational implications, as well as implications for future treatment strategies in OSA.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Polsek, D.
Gildeh, N.
Cash, D.
Williams, S.C.R.
Turkheimer, F.
Leschziner, G.D.
Morrell, M.J.
Rosenzweig, I.
Date : March 2018
Funders : Wellcome Trust
DOI : 10.1016/j.neubiorev.2017.12.004
Copyright Disclaimer : © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (
Uncontrolled Keywords : Obstructive sleep apnea; Alzheimer’s disease; Neuroinflammation; Astrocytes
Depositing User : Clive Harris
Date Deposited : 18 Sep 2019 12:49
Last Modified : 18 Sep 2019 12:49

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