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Fluid overload and acute kidney injury: Cause or consequence?

Ostermann, M., Straaten, H.M.O.-V. and Forni, Lui G. (2015) Fluid overload and acute kidney injury: Cause or consequence? Critical Care, 19 (1), 443.

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There is increasing evidence that fluid overload and acute kidney injury (AKI) are associated but the exact cause-effect relationship remains unclear. Wang and colleagues analysed patients admitted to 30 intensive care units in China and found that fluid accumulation was independently associated with an increased risk of AKI and mortality. This commentary focuses on the close pathophysiological link between AKI and fluid overload and discusses the implications for clinical practice. It outlines some of the challenges, including the difficulty in diagnosing fluid overload reliably with current methods, and stresses the importance of personalised fluid therapy with physiological end-points to avoid the deleterious effects of fluid overload.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Ostermann, M.
Straaten, H.M.O.-V.
Forni, Lui
Date : 27 December 2015
DOI : 10.1186/s13054-015-1163-7
Copyright Disclaimer : © 2015 Ostermann et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Depositing User : Diane Maxfield
Date Deposited : 01 Oct 2019 10:21
Last Modified : 01 Oct 2019 10:21

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